Production of a novel probiotic date juice with anti-proliferative activity against Hep-2 cancer cells

Date fruit is the ancient discovered and consumed fruit. Worldwide, Egypt largest producer of date. Besides its health benefits, many recent studies have proved antioxidant, anticancer anti-inflammatory effect. Currently, probiotic fermented juices a great attention especially for lactose intolerance patients. This study assessed survival two probiotics (Lactobacillus acidophilus L. sakei) in date juice. Phenolics characterization was performed by HPLC. Anti-proliferative activity juice against Caco-2 Hep-2 cell lines also evaluated. Under cold storage, sakei still live 2 weeks at 1.8 x 107 CFU/mL. In contrast, reduced from 5.2 106 CFU/mL to below minimum value products just after 1 week. sakie significantly multiplied total phenols antioxidant compared unfermented Interestingly, exhibited an antitumor larynx (Hep-2) with no Caco-2. be suitable as potential Therefore, developed recommended contribute available foodstuffs.